October 19, 2014

Acute hypervitaminosis A

Toxicity has been observed in people who have either chronically or acutely consumed more than 10 times the RDA. Hypervitaminosis A is caused by excessive intake of preformed vitamin A and has never been attributed to consumption of carotenoids.

The Tolerable Upper Intake Level (UL) for preformed vitamin A is 3,000 ug RAE (10,000 IU) per day. Ingesting larger amounts (such as 50,000 IU) of vitamin A in a short time may result in acute hypervitaminosis A.

Acute hypervitaminosis A can be defined as any toxicity manifested following the ingestion of a single very high does or several repetitive very high doses over a few days. It may occur at any age from digestion of excessive amounts of vitamin A.

Symptoms of acute hypervitaminosis A include loss of appetite, nausea, vomiting, double or blurred visions, hemorrhage, nose bleeding, increased interracial pressure, headache, dizziness, skin desquamation, and muscle incoordination.

Desquamation of the skin and mucous membranes may begin within 36 hours and becomes severe. There are no skeletal changes.
Acute hypervitaminosis 

at 8:14 PM
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